Atletico Madrid failed to build on Wednesday's notable Champions League success against Juventus when they were beaten 3-1 at a resurgent Valencia in La Liga on Saturday.
Bundesliga leaders Bayern Munich powered past third-placed Eintracht Frankfurt 4-0 with an impressive display of high-pressing football on Sunday.
While Real Madrid plot to clinch European Cup number 10, neighbours Atletico will look to thwart those plans.
Ivan Toney, once Brentford's lynchpin in attack, has moved to Al-Ahli for 40 million pounds ($52.50 million).
Defender Filipe Luis has rejoined Atletico Madrid from Chelsea in a reported 16 million euro ($17.66 million) deal, the Spanish club said.
The following is the draw for the Champions League last 16 which was held in Nyon on Monday:
A round-up of Sunday's matches in LaLiga, Ligue 1 and Serie A
United were unable to create enough quality opportunities to get themselves the goal they needed.
Real Madrid's Jude Bellingham again proved the match-winner as he struck in added time to snatch a 2-1 victory over Getafe as the Spanish giants made their home debut in La Liga this season.
Barcelona midfielder Gavi delighted to be back after 348-day injury layoff
Atletico Madrid are not seeking revenge for their 2014 Champions League final defeat but instead want to write a new chapter in the club's history with their first European Cup after getting past Bayern Munich.
Coach Diego Simeone goes home 'content' after his team's 1-0 loss in their Champions League match on Wednesday
The game, postponed from the start of the season, offered Atletico the chance to peel further away from nearest challengers Real Madrid but a second draw in three games only moved them on to 55 points.
Atletico Madrid striker Mario Mandzukic's early goal secured a 1-0 win over Real Madrid and a 2-1 aggregate success to clinch the Spanish Super Cup and gain some revenge for last season's Champions League final defeat.
'We have to move on and go ahead, it's our job. It's an important situation for the club to advance in the competition and we want to do well to honour him.'
A breathtaking individual goal from Saul Niguez put Atletico Madrid in the box seat in their Champions League semi-final against Bayern Munich with a 1-0 victory in a tense first leg on Wednesday.
'Either you're injured, and you don't play with your club and you're not called up in the national team.'
Atletico Madrid goalkeeper Jan Oblak was the hero as the Spanish side reached the UEFA Champions League quarter-finals for the fourth year in a row after drawing 0-0 with Bayer Leverkusen in an open last-16 second leg.
Luis Suarez and Lionel Messi scored stunning goals to edge Barcelona towards a fourth consecutive King's Cup final with a 2-1 win at Atletico Madrid on Wednesday, although the holders were lucky to survive a late onslaught from the hosts.
The travel ban was extended on Tuesday until March 2.
Chelsea have signed Spain World Cup striker Diego Costa from Atletico Madrid, the Stamford Bridge club said in a statement on Tuesday.
Barcelona closed to within a point of La Liga leaders Real Madrid when Lionel Messi scored one goal, created two and conceded a penalty in a 3-1 win at home to champions Atletico Madrid on Sunday that eased pressure on under-fire coach Luis Enrique.
Champions Barcelona reclaimed top spot in La Liga on Sunday by overcoming a dogged Villarreal side to win 2-0 at home with goals from stalwart defender Gerard Pique and youngster Carles Alena taking them above Sevilla.
Atletico Madrid secured a place in the Champions League qualifiers on Sunday after a goal from Diego Forlan earned them a 1-0 win over Deportivo Coruna and ensured they could finish no lower than fourth in the table. Atletico are now level on 64 points with Barca, but are in fourth because the Catalans have a better record in head-to-heads.
Fernando Torres's head injury shocked his Atletico Madrid team mates as the striker had to be carried off on a stretcher towards the end of Thursday's 1-1 draw at Deportivo La Coruna.
Atletico Madrid stayed hot on the heels of second-placed city neighbours Real Madrid when Radamel Falcao netted his 25th goal of the La Liga campaign in a scrappy 1-0 win at mid-table Sevilla on Sunday.
Chelsea forward Samuel Eto'o is out of Tuesday's Champions League semi-final first leg at Atletico Madrid because of injury.
Barcelona's Ferran Torres scored twice to help secure a late 4-2 comeback win at Atletico Madrid in a pulsating LaLiga clash on Sunday.
In the dying minutes of their Champions League semi-final second leg against Real Madrid, a thunderstorm rolled in and drenched Atletico Madrid's Vicente Calderon stadium.
Atletico Madrid right back Juanfran has thanked fans for the support he received following his penalty shootout miss in Saturday's Champions League final defeat by Real Madrid. The defender's effort rebounded off the post before Cristiano Ronaldo scored the winning spot kick to hand Real their 11th European Cup in Milan. Spain international Juanfran was in tears and did not speak to the media after the match but on Monday he wrote a letter on the club's official website. "I will never forget your displays of affection when I came to ask for your forgiveness," he said. "Seeing my tears reflected in the faces of the thousands of Atleticos that packed that end of the stadium helped me cope with the tremendous sadness I felt in those hard times."
Atletico aim for Champions League revenge against Real at fourth attempt.
A first half Tiago header set up Atletico Madrid's 2-0 victory over Espanyol as they seek to get back on track following a stuttering start to the La Liga season.
Adrian came off the bench to fire second-placed Atletico Madrid to a 1-0 La Liga home win over Celta Vigo on Friday and secure a ninth victory in nine matches this season at their Calderon stadium.
La Liga is set for one of its most thrilling finishes when Barcelona host leaders Atletico Madrid in a winner-takes-all showdown at the Nou Camp on the final day of the campaign on Saturday.
Atletico Madrid tore apart city rivals Real Madrid 4-0 at home to open up the La Liga title race on Saturday in a triumph crowned by a spectacular overhead kick goal by Saul Niguez.
Atletico said they are collaborating with authorities to identify the abusers who would be banned by the club. The Prosecutor's Office of Madrid is also investigating the case.
Villarreal and Atletico Madrid continued to struggle in La Liga after both slumped to unexpected defeats on Sunday.
Cristiano Ronaldo struck midway through the first half as leaders Real Madrid won 1-0 at Malaga in La Liga on Saturday, while Atletico Madrid stayed hot on their heels after Diego Costa netted in a 1-0 victory over Espanyol.
Atletico Madrid have signed striker Luis Suarez from Barcelona, the Spanish clubs said on Wednesday, bringing to an end his six-year stint at the Camp Nou.
